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dc.contributor.authorChekalina, N.-
dc.contributor.authorKazakov, Yu.-
dc.contributor.authorMamontova, T.-
dc.contributor.authorVesnina, L.-
dc.contributor.authorKaidashev, I. P.-
dc.contributor.authorКайдашев, Ігор Петрович-
dc.contributor.authorЧекаліна, Наталія Ігорівна-
dc.contributor.authorКазаков, Юрій Михайлович-
dc.contributor.authorМамонтова, Тетяна Василівна-
dc.contributor.authorВесніна, Людмила Едуардівна-
dc.date.accessioned2017-10-13T06:33:15Z-
dc.date.available2017-10-13T06:33:15Z-
dc.date.issued2016-
dc.identifier.citationResveratrol more effectively than quercetin reduces endothelium degeneration and level of necrosis factor α in patients with coronary artery disease / N. I. Chekalina, Yu. M. Kazakov, T. V. Mamontova [et al.] // Wiadomosci Lekarskie. – 2016. – Vol. 69, № 3 (cz II). – P. 479–483.uk_UA
dc.identifier.issn0043-5147-
dc.identifier.urihttp://elib.umsa.edu.ua/jspui/handle/umsa/1038-
dc.description.abstractObjective: to study the effect of polyphenolic antioxidants, resveratrol and quercetin, on endothelial degeneration factors in cad patients. Materials and Methods: the study involved 93 patients with coronary artery disease: stable angina pectoris, fc ii. the cytofluorometric technique was applied to define the level of circulating endothelial microparticles (emP) cd32+cd40+ in peripheral blood in order to identify ed. the content of tumor necrosis factor α (tnf-α), fibrinogen, hemocoagulation and lipid profile parameters were being determined in the blood, as well. Patients were divided into 3 groups. basic therapy (β-blockers, statins, aspirin) was prescribed to 33 persons of the comparison group, patients of the study group 1 (30 persons) additionally received resveratrol at a dose of 100 mg daily, patients of the study group 2 (30 persons) got quercetin at a dose of 3 g per day. in 2 months, the second examination of the patients was performed in the amount indicated. Results: under the influence of resveratrol a significant reduction of the level of tnf-α and the number of emP in peripheral blood was shown, in contrast to the results of other study groups. all groups showed a decrease in total cholesterol and low-density lipoprotein cholesterol, statistical differences between data of groups were not found. indicators of coagulogramma in all study groups did not change significantly, however, there was a statistically significant reduction of fibrinogen in the blood. Conclusions: resveratrol, unlike quercetin, has a positive effect on the endothelial function and systemic inflammation, which may be the result of its influence on intracellular molecular cascades associated with the nuclear transcription factor of nf-kb.uk_UA
dc.language.isoenuk_UA
dc.publisherCzasopismo Polskiego Towarzystwa Lekarskiego Wiadomości Lekarskieuk_UA
dc.subjectcoronary artery diseaseuk_UA
dc.subjectendothelial dysfunctionuk_UA
dc.subjectresveratroluk_UA
dc.subjectquercetinuk_UA
dc.subjectcirculating endothelial microparticlesuk_UA
dc.titleResveratrol more effectively than quercetin reduces endothelium degeneration and level of necrosis factor α in patients with coronary artery diseaseuk_UA
dc.typeArticleuk_UA
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